Comparison of probabilistic diffusion tensor tractography and histological tracer studies in the rhesus macaque

نویسندگان

  • Elizabeth Zakszewski
  • Jeff Moirano
  • Andrew S. Fox
  • Nagesh Adluru
  • Alexander K. Converse
  • Steve Shelton
  • Ned Kalin
  • Andrew L. Alexander
چکیده

Examinations of probabilistic tractography have identified major tracts across the brain, but little has been done to compare them to wellestablished tracer studies. Therefore, diffusion tensor imaging (DTI) probabilistic tractography of white matter (WM) was performed on a DTI template generated from 271 rhesus macaques. Injection sites from tracer experiments in literature were chosen as seed regions from which to begin tractography. Results demonstrated the probabilistic connectivity maps obtained on the DTI template were largely consistent with connectivity maps from the tracer studies.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of fiber tracts derived from in-vivo DTI tractography with 3D histological neural tract tracer reconstruction on a macaque brain

Since the introduction of diffusion weighted imaging (DWI) as a method for examining neural connectivity, its accuracy has not been formally evaluated. In this study, we directly compared connections that were visualized using injected neural tract tracers (WGA-HRP) with those obtained using in-vivo diffusion tensor imaging (DTI) tractography. First, we injected the tracer at multiple sites in ...

متن کامل

In Vivo Mapping of Fiber Pathways in the Rhesus Monkey Brain

The study of complex fiber systems in relation to the cognitive abilities of humans is a long-standing challenge for neuroscientists. With the development of diffusion tensor imaging (DTI) it is now possible to visualize large fiber bundles non-invasively. The existing knowledge of the white matter architecture largely stems from either lesion studies of human patients or, in more detail, trace...

متن کامل

Comparing Corticocortical Interconnection Information from Tracer Studies and Probabilistic Tractography in the Postmortem Macaque Brain

Introduction In an attempt to validate the corticocortical connection information we can gain from diffusion weighted MR data, we have implemented probabilistic tractography in data acquired in a macaque model and compared this with connection information already known from invasive tracer studies in the same model. The nature of the information gained from probabilistic tractography is differe...

متن کامل

3D Histological Reconstruction of Fiber Tracts and Direct Comparison with Diffusion Tensor MRI Tractography

A classical neural tract tracer, WGA-HRP, was injected at multiple sites within the brain of a macaque monkey. Histological sections of the labeled fiber tracts were reconstructed in 3D, and the fibers were segmented and registered with the anatomical post-mortem MRI from the same animal. Fiber tracing along the same pathways was performed on the DTI data using a classical diffusion tracing tec...

متن کامل

Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex

Diffusion magnetic resonance imaging (MRI) allows for the noninvasive in vivo examination of anatomical connections in the human brain, which has an important role in understanding brain function. Validation of this technique is vital, but has proved difficult due to the lack of an adequate gold standard. In this work, the macaque visual system was used as a model as an extensive body of litera...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011